Use of enzyme immunoassay as treponemal screening test in syphilis diagnosis
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WL Leung ±ç°¶½¬ and KM Kam ¥Ì±Ò¤å

Serological methods play a major role in the diagnosis and treatment monitoring of syphilis infection. With the development and commercial availability of well performing syphilis enzyme immunoassays (EIAs), many laboratories are switching from their traditional nontreponemal screening algorithm to new EIA treponemal screening strategy. Recent experiences have been gained on testing with different EIA antigens as well as amongst different at-risk populations e.g. pregnancy, HIV. This paper reviews these developments, evaluations and practices of treponemal EIAs and aims to provide an overview on its practical application for syphilis laboratory diagnosis in Hong Kong. (Hong Kong J. Dermatol. Venereol. (2006) 14, 189-195)

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Keywords : Enzyme immunoassay, laboratory diagnosis, syphilis, Treponema pallidum

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